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ResearchThe Biochemical Effects
of Oxygen Deficiency
When fuel is burned inside of the
mitochondria, energy, water and carbon dioxide are produced. When
there is insufficient oxygen for the combustion of fuel, lactic acid
is produces, and carbon dioxide and water are not produced. This
article will discuss the consequence of insufficient oxygen on the
metabolism.
Lactic acid
The first step in energy production in the cell
is the breaking down of fuel into smaller pieces. This step
requires no oxygen, and is responsible for 5% of our energy
production. If there is sufficient oxygen available to the system,
the next step is the oxidation of these smaller fuel pieces yielding
the remaining 95% of our oxygen requirements. If however there is
insufficient oxygen for this process to take place, then the body is
limited to 5% of it's energy potential and lactic acid is generated
for the unburned fuel. Lactic acid has three main negative effects
in the body. First, lactic acid causes the acidification of the
tissues of the body. Secondly, lactic acid requires oxygen for it's
metabolism, so the lactic acid in the body represents an oxygen debt
that must be paid for, usually in a body already low in oxygen.
This debt is usually paid for by the liver, so lactic acid causes
liver hypoxia. Oxygen is an extremely important cofactor in many
detoxification pathways in the liver, so lactic acid also impairs
the liver's detoxification ability. Thirdly, lactic acid is know to
increase anxiety levels (injected lactic acid can precipitate a
panic attack). Thus, insufficient oxygen, and it's corollary
increase in lactic acid has several negative biochemical outcomes.
Insufficient energy production
Insufficient oxygen limits the body to 5% of
it's potential energy production. The global consequences of this
are obvious, such as fatigue, and diminished atp, but indirectly,
it also means weight gain and/or increased blood sugar should fat
production by inefficient since the unburned fuel must be
sequestered if it cannot be combusted
Insufficient cellular water
As we age, our bodes go from 80% hydration to 50%
hydration. Why can't we simply drink more water to make up for this
loss? The reason is that it is our cellular water that is being
lost as we age. Cellular water is produced by the burning of
carbohydrates (sugars) with oxygen yielding carbon dioxide and
water. Thus, insufficient oxygen means insufficient cellular
water. The effects of dehydration on the body will not be discussed
here. For a thorough study o the effects of dehydration, please
read "Your body's many cries for water" by F. Batmanghelidj M.D.
Insufficient carbon dioxide
The final consequence of low oxygen is insufficient
carbon dioxide production. While considered by many to be a waste
gas, carbon dioxide is actually a hormone on par with NO (nitrous
oxide) another gaseous hormone. Carbon dioxide is required for the
relaxation of smooth muscle cells and maintaining the correct
sensitivity for nerve cells. An insufficiency of carbon dioxide
will cause smooth muscle cells to contract and nerve cells to fire
excessively. Carbon dioxide is also required for the efficient
delivery of oxygen to the tissues.
Smooth muscle cells
Smooth muscle cells are found in all parts of the
body. Here are some examples of their locations as well as the
symptoms they would create
Smooth muscle cells in the circulator
system--Headaches, strokes, angina heart attacks, cold hands and
feet and high blood pressure
In the throat- choking
In the vocal cords - speech difficulties
In the stomach- gastric reflux
In the intestines - irritable bowel syndrome and
constipation
In the gall bladder- gall stones
In the lungs- asthma
In the male reproductive organ- impotence
The bladder- incontinence
In the face- wrinkles (hence the use of Botox to
relax facial muscles and reduce wrinkle appearance)
One quick test to determine the level smooth
muscle contraction is to put a blood pressure cuff around the calf
muscle. Inflate slowly and find the pressure at which the muscle is
uncomfortable. This value should be over 250. The lower the value,
the more tense the muscles. If this number is below 120, the client
may be at risk for a sudden heart attack. This is because cramps in
the heart (angina) play a major role in heart attacks. The
majority of fatal heart attacks do not on postmortem examination
reveal blockages of the coronary arteries sufficient to explain the
heart attack. It is the "cramping" of the heart muscle that
triggers the fatal attack.
Excessive nerve firing
Insufficient carbon dioxide will also cause nerves
to fire excessively which can result in:
epilepsy, stuttering, anxiety, obsessive compulsion,
ADD-ADHD, muscle tension, tremors and tics, chronic pain and
premature ejaculation.
Oxy-hemoglobin disassociation curve
Insufficient carbon dioxide also shifts the
oxy-hemoglobin disassociation curve making the transport and
delivery of oxygen less efficient, further decreasing carbon dioxide
in turn
Conclusion
Most clients present with acceptable levels of
oxygen in their blood, yet still have the clinical symptoms of
hypoxia. This is because it is the delivery of the oxygen that is
to blame. In this way, chelation helps to increase the deliverable
oxygen to the body thereby relieving the host of secondary
manifestations that it products.
Magnesium Di-potassium EDTA suppositories have shown to increase
blood carbon dioxide levels on average 3 points in 10 days.
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