Saw Palmetto Benign Prostatic Hyperplasia and Endosterol Part 1

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“The efficacy of Saw Palmetto has been demonstrated by a hierarchy of research designs, the least rigorous designs being uncontrolled, open clinical trials.25-56 Most uncontrolled studies lasted less than 3 months, but some studies continued up to 1 year44 and 3 years.48 The potency of SPE over placebo has been proven in
double-blind, randomized studies.57-76

One dissenting study showed SPE was no better than placebo.77 SPE has been compared to pharmaceutic drugs. It worked better than gestonorone caproate, an antiandrogen agent,78 but was less effective than two _1-adrenergic antagonists, prazosin hydrochloride79 and alfuzosin.80 A large, 6-month trial compared Saw Palmetto to finasteride; the drugs produced comparable symptomatic improvements, although Saw Palmetto caused less sexual dysfunction than finasteride.81 A recent study reported similar findings—
no significant differences between Saw Palmetto and finasteride in resolving symptoms of Benign Prostatic Hyperplasia, but Saw Palmetto had fewer side effects.

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