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Ellagica
Broad-Spectrum: Anti-Viral, Anti-Bacterial, Anti-Fungal,
Anti-Parasitical, Anti-Cancer,
Anti-Oxidant, Anti-Mutagenic and Cardio Protective Properties for
the Immune System
Pomegranate, walnuts and red raspberries are examples of rich
dietary sources of ellagic acid and the precursors to ellagic acid
called ellagitannins. Some dietary ellagic acid is converted in your
intestines into compounds called urolithins, which are also absorbed
and may be responsible for some of the health benefits of ellagic
acid. Ellagic acid and its metabolic products appear to have
anti-cancer properties, especially against prostate cancer.
Sources and Metabolism
Ellagic acid is a small phytochemical that can occur naturally in
foods, and it also can be produced as a breakdown product of larger
phytochemicals called ellagitannins in your intestines. Many plant
foods contain some ellagic acid. In addition to pomegranate, foods
with relatively high levels include strawberries, blackberries,
raspberries, cranberries, walnuts and pecans. Absorption of ellagic
acid from food occurs quite rapidly, with maximum levels in your
blood after about one hour, after which blood levels decline as
ellagic acid is metabolized to other compounds.
Prostate Cancer
Ellagic acid metabolic products are found concentrated in prostate
tissues of male mice fed pomegranate ellagitannins. In human
subjects with prostate cancer or enlargement who were provided
walnuts or pomegranate juice for the three days just prior to
surgery, metabolic products of ellagic acid were found to be
concentrated in prostate tissue, according to a study published in
the March 2010 issue of “Molecular Nutrition and Food Research.” A
study presented in the July 1, 2006, issue of “Clinical Cancer
Research” reported a reduction in prostate cancer disease
progression following surgery in patients given 8 ounces of
pomegranate juice per day.
Obesity and Inflammation
Obesity is a condition of overweight that involves inflammation in
your fatty tissues. Ellagic acid was found to lower fatty tissue
levels of an inflammatory compound called resistin in mice,
according to a study in the Jan. 13, 2012, issue of "Biochemical and
Biophysical Research Communications." High blood levels of resistin
in people are associated with diabetes and coronary artery disease
and can be caused by white blood cell infiltration of fatty tissues.
Although ellagic acid has not been shown to inhibit resistin
production in people, pre-clinical work suggests a possible
anti-inflammatory effect in obesity-related diseases.
Glucose Metabolism
Ellagitannins from strawberries were found to be inhibitors of
pancreatic amylase, which slows initial steps of starch digestion,
as reported in the Oct. 2010 issue of the “Journal of Medicinal
Food.” The final step in starch digestion to glucose for absorption
is facilitated by an intestinal enzyme called alpha-glucosidase.
Ellagic acid is an inhibitor of alpha-glucosidase. Thus,
ellagitannins and ellagic acid may decrease the rate of glucose
entry into the bloodstream following a meal. Most ellagic acid in
strawberries and raspberries is found in the seeds and pulp, with
much lower amounts in the juices.
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