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Effects of Magnesium
Di-Potassium EDTA suppositories on
blood chemistry values
ABSTRACT: Two studies were completed using 21 and
16 patients respectively measuring the effects of Magnesium
Di-Potassium EDTA suppositories on standard blood chemistry values.
Liver enzymes remain unchanged. BUN/creatinine ratios, bilirubin
levels and prothrombin times all showed normalization towards
optimal values whether initially high or low. 92% of the subjects
had an increase in CO2 levels indicating increases in metabolism. We
conclude that Magnesium Di-Potassium EDTA suppositories are
absorbed, safe and effective.
Methods and Materials
21
subjects had their blood drawn. Immediately thereafter, they
inserted one 333 mg Magnesium Di-Potassium EDTA suppository
rectally. 30 minutes later their blood was drawn again. Subjects
were told not to change their lifestyle or eating habits. The
subjects were then given ten more suppositories and were told to
take one per night for ten nights. 11 days later the subjects had
their blood drawn again. Some clients had their blood drawn on
the12th day and they were given 2 extra suppositories. Of the 21
subjects initially begun with, 5 did not take a second blood draw.
One patient revealed that he was on the antibiotic Cipro for a sinus
infection, one patient was stung by a jellyfish, one subject began
supplementation along with the chelation, one client found the
chelation uncomfortable and did not continue and a final patient was
not eligible for long term studies since he had already undergobe
Chelation Therapy previously. A standard blood chemistry was done
along with measurements of phosphorous, uric acid, prothrombin time
and lipid profiles. 333 mg of Magnesium Di-Potassium EDTA yields the
same amount of EDTA as 303.8 mg of Di-sodium EDTA. Ten suppositories
therefore have the same amount of EDTA as a 3.03 gram I.V. of
Di-sodium EDTA.
Results
Figures 1 and 2 show the normalizing effect of the suppository form
of Magnesium Di-Potassium EDTA on kidney function. Figures 3 and 4
show that there is no stress to the liver as measured liver enzymes
remaining stable. Figure 5 shows a normalizing effect on prothrombin
time. Figure 6 shows a global increase in the blood CO2 levels
indicating an increase of oxygenation and an increase in metabolic
efficiency. Figure 7 shows a normalizing effect on bilirubin.
Figures 1 and 2 BUN/Creatinine ratios (10 days)
Figure 1 shows the change in BUN/creatinine ratios after 10 days.
The X-axis represents the original BUN/creatinine ratio; the Y-axis
represents the change in that ratio after the Magnesium Di-Potassium
EDTA. Figure 2 is the same data with the non-conforming data-point
removed. This client’s BUN went from 30 to 18 and her creatinine
went from 1.2 to 0.7. While this does not yield a change in the BUN/creatinine
ratio it obviously implies an incredible regeneration of kidney
function in a short period of time.
Figure 3 SGOT levels (10 days)
Figure 4 SGPT levels (10 days)
Figure 5 Prothrombin time (30 minutes)
Figure 6 Bilirubin levels (10 days)
The
X-axis represents the PT time and the Y-axis represents the change
in pre and post values.
Prothrombin time tests were performed using the ProTime
microcoagulation
system (ITC, Edison, NJ) point of care monitor.
Figure 7 CO2 levels (10 days) Figure 8 Sodium levels
(10 days)
Discussion
In
redesigning both the method of administration and the type of
ingredient used in chelation, there are two questions to answer. Is
it safe, and is it effective? Figures 1 and 2 show that not only is
there no apparent damage to the kidney function, there is actually
an improvement as measured by the normalization of the BUN/creatinine
ratios. Low values moved higher and the high values dropped lower.
In addition, the farther from the norm the values initially were,
the greater the change seen towards the norm. I.V. chelation also
shows this normalizating effect1 but typically only after
an initial and reversible glomerulonephritis. We believe that the
smaller and more frequent application of suppository EDTA is safer
on the kidneys than the less frequent but more intense therapies
given intravenously as evidenced here. Figures 3 and 4 show no
effect on liver enzymes, further indication of the safety of this
protocol.
Figure 5 shows a normalizing effect on prothrombin time after one
suppository. Low values moved up and high values moved down. Similar
to the BUN/creatinine tests, the farther from the norm the initial
values were, the greater the change towards normal. The initial
values of the PT time, while higher than normal in both pre and
post, are appropriate for the device and analyate used. The point to
which the protocol drove the post values is higher than considered
normal for the device, but considering that coagulation accounts for
the first and third causes of death in this country (heart attacks
and strokes) this norm value may not be the optimal value for
health. A higher value like the one achieved with this protocol may
be preferable.
Figure 6 shows a normalizing effect on the total bilirubin levels.
Similar to the BUN/creatinine and prothrombin tests, the farther
from the norm the initial values were, the greater the change
towards normal. High bilirubin levels indicate excessive breakdown
of hemoglobin and/or biliary obstruction. While the literature is
silent regarding low bilirubin, we suspect this may be indicative of
spleenic, liver or bone marrow dysfunction since bilirubin is the
end-product of hemoglobin breakdown by these sites.
Figure 7 shows an increase in the CO2 levels in 93.75% of the
subjects. The average increase was 3.125 mEq/L. The average CO2
level of the subjects went from
24.625 mEq/L to
27.75 mEq/L. While reference ranges for CO2 are 23 to 29, optimal
values are 26 to 312 with 28.5 being the center-point. to
In human metabolism, food and oxygen are combusted to release energy
water and carbon dioxide. Since none of the subjects changed their
eating patterns, an increase in CO2 means greater oxygen use and
more efficient metabolism. It is not a matter of absorbing more
oxygen from the air since for most people, pulse oximetry will show
near saturation of the hemoglobin with oxygen. Rather it indicates
that the oxygen that the clients already had in their blood was now
being more efficiently delivered to the tissues. This increase of
metabolism and oxygen uptake may be of value not only to clients
looking for more energy, but also for clients trying to lose weight
and athletes looking for a competitive edge.
Decreased CO2 levels lower pain thresholds cause adrenalin to be
released into the blood. As CO2 continues to drop, cells produce
lactic acid to reduce alkalinity causing fatigue, numbness,
tingling and anesthesia. Low CO2 also stimulates the smooth muscle
to contract, constricting blood vessels, particularly to the heart
and brain. Low CO2 also causes mast cells to release histamine and
other mediators causing further blood vessel constriction. Adequate
CO2 helps maintain blood pH at 7.4 and represents the reserve of
alkali readily available for the neutralization of acids.
Figure 8 shows 8 --7.5% of the subjects having an
average drop of 3.125
in their
sodium levels
in their
sodium levels. The improvement in kidney function rules out kidney
dysfunction as a cause for the drop. Thus Magnesium Di-Potassium
EDTA may be beneficial for those looking to lower sodium values.
In
addition, 69% of the subjects had a drop of an average of 47 points
in their triglycerides, 56.25% had a drop of an average of 3.9 in
their calcium levels while those whose calcium increased, only did
so by on average 1.7. Aside from the traditional interpretation,
normalization of triglycerides is also associated with an
improvement in glucose control and as Magnesium Di-Potassium EDTA
may be beneficial for those with dysinsulinism (syndrome X).
Conclusion
Chelation by suppository with Magnesium Di-Potassium EDTA in
suppository form is both safe and effective and represents a valid
alternative to intravenous chelation with Di-sodium EDTA. In
addition, Magnesium Di-Potassium EDTA also has shown to have certain
beneficial effects not associated with the traditional Di-sodium
form of EDTA.
References
1
The effect of EDTA chelation therapy and supportive
multivitamin/trace mineral supplementation upon renal function. A
study in Serum Creatine. E.W. McDonagh, DO, C.J. Rudolph, PhD, DO,
and E. Cheraskin, MD, DMD .
2 Balancing body chemistry with nutrition
seminars. Third Revision – January 2000 page 39.
The following is a letter from Dr. Halstead,
considered by many to be the
father of modern chelation
An Open Letter To
Whom It May Concern
31 May 2000
I have been involved in the development of the EDTA suppositories
since the idea was first conceived seven years ago. The suppository
delivery system was developed because it meets a special need. The
primary purpose was to produce a drug delivery system that was
painless and effective for children and for adults that found it
difficult to take chelation therapy because of time constraints.
Research
studies showed that the uptake of EDTA was effective by the colonic
route. The low molecular weight of EDTA of 292.1 facilitates
efficient absorption through the colon wall. Moreover, there is an
additional safety factor because it is in a special time release
formulation. There is clinical evidence available that the
suppository is not only safe, but it is effective. It is my
professional opinion that approximately 90% or more of the EDTA is
absorbed through the colon. For additional information on this
subject it will be helpful to review my book, The Scientific
Basis of EDTA Chelation Therapy, by Halstead and Rozema 1977.
Keep up the good
work.
Best Regards,
Bruce W. Halstead, M.D.
Director
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