Antioxidant Ellagic Acid Found In Berries, Other Foods Prevents UV Skin Damage That Leads To Wrinkles Part 3

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During these eight weeks, half of the exposed mice were given daily 10 microM topical applications of ellagic acid on their skin surface, even on the days in which they did not receive UV exposure. The other mice, also exposed to UV light, did not receive ellagic acid. (Another six mice served as controls, with neither UV exposure nor ellagic acid.)

What happened? First, as expected, the mice exposed to UV radiation without the ellagic acid treatment developed wrinkles and thickening of the skin.

Second, as hypothesized, the exposed mice that received topical application of ellagic acid showed reduced wrinkle formation.
Third, as suggested in the study of human cells, the ellagic acid reduced inflammatory response and MMP secretion due to protection from the degradation of collagen. The ellagic acid also helped prevent an increase of epidermal thickness.

The researchers say the results demonstrate that ellagic acid works to prevent wrinkle formation and photo-aging caused by UV destruction of collagen and inflammatory response.

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